DNA Replication Musical

DNA Replication Script

*Time to Replicate DNA*

Students: *Soooo I tell you what I want what i really really want. So tell me what you want what you really really want. I’ll tell you what i want what i really really want. So tell me what you want what you really really want. I wanna, I wanna, I wanna, I wanna, I wanna really really really wanna replicate DNA*

Student: Wait how do we do that again?

Student: Also what is DNA?

Teacher: *DNA is a thing in your bodyyyy. To store information. About how to make the perfect human. Like you or me!!*

Teacher: And about how to replicate it, *We can show you how. To replicate DNA!*

Teacher: *Okay so first things first, unwind the helix. My man Helicase starts the process. Gotta keep it stable with them single stranded proteins. You don’t wanna start a process like this*

Teacher: Next comes my man DNA Polymerase III! *Shout out Polymerase III! You’re really quite the enzyme! You made my bases and that made me who I am!*

DNA Polymerase III: *in masculine voice* why thank you ladies!

Student: Wow! This Polymerase guy seems so perfect! *Who says? Who says it’s not perfect?*

Student: I know right!

Teacher: Haha I say it’s not perfect! It has limits! See?

{Video cuts to DNA Polymerase III}

DNA Polymerase III: *What would I give? If I could build… 3 to 5 prime…. What would I pay? To synthesize without RNA primer….*

Teacher: *That poor unfortunate soul! So sad and helpless. It cannot add DNA without some RNA primer first. By Primase? Yes, Indeed. That poor unfortunate soul!! It needs some help! It only adds 5 to 3 prime, not the other way around. What’s the solution? Let me show you!*

Teacher: *Piece by piece. It works on the lagging strand. With okazaki fragments oh! Piece by piece! It works 5 to 3. Slowly as the DNA unravels.*

Student: Ohhhh that’s so cool! DNA Polymerase seems to work so fast! *It’s just as swift as a coursing river!!*

Student: Wait but doesn’t it need autocorrect or something? It has to make some mistakes!

Teacher: Well that’s why we have DNA Polymerase I

{Video cuts to DNA Polymerase I and DNA}

DNA Polymerase I: *So it’s a bit of a fixer upper. So it’s kind of cray. But that’s okay because I’m the autocorrect of DNA!!*

Student: Wait so just these few enzymes have to make sure that multiple chromosomes are replicated?

Teacher: Haha no silly! There are millions of replication sites on just one chromosome.

The Cell: *And at last I see more DNA! Their double helixes are perfect*

Teacher: *Two whole new strands!!!! A hundred thousand proteins to make!*

*ATATCGCG… I’m in love with the Chargaff’s Rules*